Medicine

Accelerating ASO therapies coming from development to application

.Contending enthusiasms.R.S., M.S., H.G. as well as A.A.R. are planners of the 1M1M project. H.G. and also A.A.R. are actually board of supervisors participants as well as R.S., M.S. and A.A.R. are actually members of the medical advising board of N1C. A.A.R. divulges work by LUMC, which possesses licenses on exon-skipping technology, a number of which has actually been certified to BioMarin as well as consequently sublicensed to Sarepta. As co-inventor of a number of these licenses, A.A.R. was actually qualified to an allotment of aristocracies. A.A.R. further discloses working as impromptu expert for PTC Therapies, Sarepta Therapeutics, Regenxbio, Dyne Therapies, Lilly, BioMarin Pharmaceuticals Inc., Eisai, Entrada, Takeda, Splicesense, Galapagos, Sapreme, Italfarmaco and Astra Zeneca. Over the last 5 years, A.A.R. likewise did speaking to for Alpha Anomeric. A.A.R. likewise states registration of the scientific boards of advisers of Eisai, Hybridize Therapies, Muteness Therapies, Sarepta Therapies, Sapreme as well as Mitorx. Previously 5 years, A.A.R. was also a clinical board of advisers participant for ProQR. Compensation for A.A.R. u00e2 s consulting as well as suggesting activities is paid for to LUMC. Before 5 years, LUMC additionally obtained speaker honoraria coming from PTC Therapies, Alnylam Netherlands, Italfarmaco and also Pfizer and moneying for agreement study coming from Sapreme, Eisai, Galapagos, Synaffix and Alpha Anomeric. Job financing is obtained coming from Sarepta Therapies and also Entrada using unregulated grants. H.G. has nothing at all to divulge in relation to the topics dealt with within this manuscript. In the past 5 years, he has actually likewise acquired consultancy gratuity from UCB. M.S. obtained working as a consultant gratuity from Ionis, UCB, Prevail, Orphazyme, Biogen, Servier, Reata, GenOrph, AviadoBio, Biohaven, Zevra, Lilly as well as Solaxa before 5 years, all unassociated to the present composition. R.S. possesses nothing at all to make known relative to the subjects covered in this composition. She has actually received audio speaker and/or consultancy honoraria or funding contributions coming from Abbvie, Bial, STADA and also Everpharma in the past 5 years.